Location bias contributes to functionally selective responses of biased CXCR3 agonists

Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many subcellular compartments. Here, we determine that diff...

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Detalles Bibliográficos
Autores principales: Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532441/
https://www.ncbi.nlm.nih.gov/pubmed/36195635
http://dx.doi.org/10.1038/s41467-022-33569-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532441/
https://www.ncbi.nlm.nih.gov/pubmed/36195635
http://dx.doi.org/10.1038/s41467-022-33569-2

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