Effect of CYP3A4 and PPARA polymorphism on concentration-to-dose ratio and adverse effects of tacrolimus in Pakistani liver transplant recipients

OBJECTIVES: Polymorphism in cytochrome P450 3A4 (CYP3A4) and its regulatory gene peroxisome proliferator activated receptor (PPARA) may significantly affect the metabolism of tacrolimus. This study aims to explore the effect of the single nucleotide polymorphisms (SNP) of cytochrome P450 3A4 and PPA...

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Detalles Bibliográficos
Autores principales: Azam, Fahad, Khan, Moosa, Shaheen, Abida, Bhatti, AbuBakar Hafeez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532634/
https://www.ncbi.nlm.nih.gov/pubmed/36246675
http://dx.doi.org/10.12669/pjms.38.7.6180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532634/
https://www.ncbi.nlm.nih.gov/pubmed/36246675
http://dx.doi.org/10.12669/pjms.38.7.6180

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