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Effect of CYP3A4 and PPARA polymorphism on concentration-to-dose ratio and adverse effects of tacrolimus in Pakistani liver transplant recipients
OBJECTIVES: Polymorphism in cytochrome P450 3A4 (CYP3A4) and its regulatory gene peroxisome proliferator activated receptor (PPARA) may significantly affect the metabolism of tacrolimus. This study aims to explore the effect of the single nucleotide polymorphisms (SNP) of cytochrome P450 3A4 and PPA...
Autores principales: | Azam, Fahad, Khan, Moosa, Shaheen, Abida, Bhatti, AbuBakar Hafeez |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532634/ https://www.ncbi.nlm.nih.gov/pubmed/36246675 http://dx.doi.org/10.12669/pjms.38.7.6180 |
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