Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug prescribed for treatment of atrial fibrillation (AF) induces cardiac adverse effects (AEs) with poorly understood mechanisms. We previously demonstr...

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Detalles Bibliográficos
Autores principales: Karkhanis, Aneesh V., Venkatesan, Gopalakrishnan, Kambayashi, Ryuichi, Leow, Jacqueline Wen Hui, Han, Marcus Qingrui, Izumi-Nakaseko, Hiroko, Goto, Ai, Pang, Jeremy Kah Sheng, Soh, Boon Seng, Kojodjojo, Pipin, Sugiyama, Atsushi, Chan, Eric Chun Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532722/
https://www.ncbi.nlm.nih.gov/pubmed/36213535
http://dx.doi.org/10.1016/j.apsb.2022.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532722/
https://www.ncbi.nlm.nih.gov/pubmed/36213535
http://dx.doi.org/10.1016/j.apsb.2022.03.008

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