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The roles of the tumor suppressor parafibromin in cancer

In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease. CDC73 is transcriptionally downregulated by the Wilms’ tumor suppressor gene WT1 and translationally targeted by...

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Detalles Bibliográficos
Autores principales: Zheng, Hua-chuan, Xue, Hang, Zhang, Cong-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532749/
https://www.ncbi.nlm.nih.gov/pubmed/36211470
http://dx.doi.org/10.3389/fcell.2022.1006400