Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability

DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads to DNA damage and genomic instability. Replication stress is commonly associated with slow and stalled replication forks. Recently, accelerated replication has emerged as a non-ca...

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Detalles Bibliográficos
Autores principales: Sarni, Dan, Barroso, Sonia, Shtrikman, Alon, Irony-Tur Sinai, Michal, Oren, Yifat S., Aguilera, Andrés, Kerem, Batsheva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532845/
https://www.ncbi.nlm.nih.gov/pubmed/36170822
http://dx.doi.org/10.1016/j.celrep.2022.111397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532845/
https://www.ncbi.nlm.nih.gov/pubmed/36170822
http://dx.doi.org/10.1016/j.celrep.2022.111397

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