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Pronounced antiseizure activity of the subtype‐selective GABA(A) positive allosteric modulator darigabat in a mouse model of drug‐resistant focal epilepsy

AIM: Darigabat is an α2/3/5 subunit‐selective positive allosteric modulator of GABA(A) receptors that has demonstrated broad‐spectrum activity in several preclinical models of epilepsy as well as in a clinical photoepilepsy trial. The objective here was to assess the acute antiseizure effect of dari...

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Detalles Bibliográficos
Autores principales:	Gurrell, Rachel, Iredale, Philip, Evrard, Alexis, Duveau, Venceslas, Ruggiero, Céline, Roucard, Corinne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532903/ https://www.ncbi.nlm.nih.gov/pubmed/35965432 http://dx.doi.org/10.1111/cns.13927

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