Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder

INTRODUCTION: CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental condition, primarily affecting girls for which no cure currently exists. Neuronal morphogenesis and plasticity impairments as well as metabolic dysfunctions occur in CDD patients. The present study explored the potential ther...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia, Cosentino, Livia, Urbinati, Chiara, Talamo, Maria Cristina, Medici, Giorgio, Quattrini, Maria Cristina, Mottolese, Nicola, Pietraforte, Donatella, Fuso, Andrea, Ciani, Elisabetta, De Filippis, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532911/
https://www.ncbi.nlm.nih.gov/pubmed/35932179
http://dx.doi.org/10.1111/cns.13907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532911/
https://www.ncbi.nlm.nih.gov/pubmed/35932179
http://dx.doi.org/10.1111/cns.13907

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