Golexanolone, a GABA(A) receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation

AIMS: Hyperammonemic rats show peripheral inflammation, increased GABAergic neurotransmission and neuroinflammation in cerebellum and hippocampus which induce motor incoordination and cognitive impairment. Neuroinflammation enhances GABAergic neurotransmission in cerebellum by enhancing the TNFR1‐gl...

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Detalles Bibliográficos
Autores principales: Mincheva, Gergana, Gimenez‐Garzo, Carla, Izquierdo‐Altarejos, Paula, Martinez‐Garcia, Mar, Doverskog, Magnus, Blackburn, Thomas P., Hällgren, Anneli, Bäckström, Torbjörn, Llansola, Marta, Felipo, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532914/
https://www.ncbi.nlm.nih.gov/pubmed/35880480
http://dx.doi.org/10.1111/cns.13926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532914/
https://www.ncbi.nlm.nih.gov/pubmed/35880480
http://dx.doi.org/10.1111/cns.13926

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