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Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability
AIMS: Exosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate the function of dysfunctional chondrocyte-derived exo (DC-exo) on OA in rats and rat macrophages. METHODS: Rat-derived chondrocytes were isolated, and DCs induced with interleukin (IL)-1β wer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Editorial Society of Bone & Joint Surgery
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533253/ https://www.ncbi.nlm.nih.gov/pubmed/36066338 http://dx.doi.org/10.1302/2046-3758.119.BJR-2021-0443.R2 |