SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell...

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Detalles Bibliográficos
Autores principales: Samudyata, Oliveira, Ana O., Malwade, Susmita, Rufino de Sousa, Nuno, Goparaju, Sravan K., Gracias, Jessica, Orhan, Funda, Steponaviciute, Laura, Schalling, Martin, Sheridan, Steven D., Perlis, Roy H., Rothfuchs, Antonio G., Sellgren, Carl M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533278/
https://www.ncbi.nlm.nih.gov/pubmed/36198765
http://dx.doi.org/10.1038/s41380-022-01786-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533278/
https://www.ncbi.nlm.nih.gov/pubmed/36198765
http://dx.doi.org/10.1038/s41380-022-01786-2

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