Losartan as an ACE inhibitor: a description of the mechanism of action through quantum biochemistry

Losartan (LST) is a potent and selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist widely used in the treatment of hypertension. The formation of Ang II is catalyzed by the angiotensin I-converting enzyme (ACE) through proteolytic cleavage of angiotensin I (Ang I), which is involved i...

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Detalles Bibliográficos
Autores principales: Bezerra, Eveline M., de Alvarenga, Érika C., dos Santos, Ricardo P., de Sousa, Jeanlex S., Fulco, Umberto L., Freire, Valder N., Albuquerque, Eudenilson L., da Costa, Roner F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533318/
https://www.ncbi.nlm.nih.gov/pubmed/36320533
http://dx.doi.org/10.1039/d2ra04340h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533318/
https://www.ncbi.nlm.nih.gov/pubmed/36320533
http://dx.doi.org/10.1039/d2ra04340h

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