QSAR models reveal new EPAC-selective allosteric modulators

Exchange proteins directly activated by cAMP (EPAC) are guanine nucleotide exchange factors for the small GTPases, Rap1 and Rap2. They regulate several physiological functions and mitigation of their activity has been suggested as a possible treatment for multiple diseases such as cardiomyopathy, di...

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Detalles Bibliográficos
Autores principales: Mohamed, Hebatallah, Shao, Hongzhao, Akimoto, Madoka, Darveau, Patrick, MacKinnon, Marc R., Magolan, Jakob, Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533425/
https://www.ncbi.nlm.nih.gov/pubmed/36320893
http://dx.doi.org/10.1039/d2cb00106c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533425/
https://www.ncbi.nlm.nih.gov/pubmed/36320893
http://dx.doi.org/10.1039/d2cb00106c

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