Cargando…

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer

BACKGROUND: Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRMTs are currently in the early phases of clinical trials and more candidate drug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuangjie, Liu, Zhuonan, Piao, Chiyuan, Zhang, Zhe, Kong, Chuize, Yin, Lei, Liu, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533510/ https://www.ncbi.nlm.nih.gov/pubmed/36199122 http://dx.doi.org/10.1186/s13046-022-02500-4

Ejemplares similares

Non‐metabolic function of MTHFD2 activates CDK2 in bladder cancer
por: Liu, Xi, et al.
Publicado: (2021)

METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression
por: Liu, Zhuonan, et al.
Publicado: (2021)

METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
por: Liu, Zhuonan, et al.
Publicado: (2022)

Genome-Wide Analyses of Prognostic and Therapeutic Alternative Splicing Signatures in Bladder Urothelial Carcinoma
por: Fan, Zhongru, et al.
Publicado: (2021)

Overexpression of UNC5B in bladder cancer cells inhibits proliferation and reduces the volume of transplantation tumors in nude mice
por: Kong, Chuize, et al.
Publicado: (2016)

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer
por: Piao, Chiyuan, et al.
Publicado: (2018)

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
por: Man, Xiaojun, et al.
Publicado: (2019)

Correction to: USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
por: Man, Xiaojun, et al.
Publicado: (2021)

miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expression
por: Cui, Xiaolu, et al.
Publicado: (2016)

The flavokawains: uprising medicinal chalcones
por: Abu, Nadiah, et al.
Publicado: (2013)

RUNX2 interacts with SCD1 and activates Wnt/β‐catenin signaling pathway to promote the progression of clear cell renal cell carcinoma
por: Song, Xiandong, et al.
Publicado: (2022)

Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer
por: Brobbey, Charles, et al.
Publicado: (2023)

The Sigma‐2 Receptor/TMEM97 Agonist PB28 Suppresses Cell Proliferation and Invasion by Regulating the PI3K‐AKT‐mTOR Signalling Pathway in Renal Cancer
por: Zhan, Bo, et al.
Publicado: (2021)

FBXO30 functions as a tumor suppressor and an E3 ubiquitin ligase for hZIP1-mediated HIF-1α degradation in renal cell carcinoma
por: Yuan, Yulin, et al.
Publicado: (2023)

PRMT5 inhibitors on the (myeloma) road
por: Gulla, Annamaria, et al.
Publicado: (2018)

Targeted inhibition of Polo‐like kinase 1 by a novel small‐molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells
por: Zhang, Zhe, et al.
Publicado: (2016)

Role of PRMT5 in bladder cancer: a comprehensive study
por: Ma, Yingxin, et al.
Publicado: (2019)

Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway
por: Liu, Zhongbo, et al.
Publicado: (2017)

The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells
por: Huang, Yexiang, et al.
Publicado: (2020)

HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4
por: Yu, Meng, et al.
Publicado: (2020)

Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer
por: Li, Juan, et al.
Publicado: (2020)

Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells
por: Liu, Xi, et al.
Publicado: (2019)

Exploring the five different genes associated with PKCα in bladder cancer based on gene expression microarray
por: Zhang, Xiaotong, et al.
Publicado: (2021)

Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer
por: Song, Liankun, et al.
Publicado: (2022)

Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study
por: Jing, Shaoze, et al.
Publicado: (2022)

Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA
por: Yu, Chunping, et al.
Publicado: (2022)

Primary bladder schwannoma: a case report and literature review
por: Xu, Yanlong, et al.
Publicado: (2021)

TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner
por: Liu, Liu, et al.
Publicado: (2023)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

High PRMT5 expression is associated with poor overall survival and tumor progression in bladder cancer
por: Tan, Lei, et al.
Publicado: (2020)

Construction and analysis of a ceRNA network and patterns of immune infiltration in bladder cancer
por: Fu, Yang, et al.
Publicado: (2021)

Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer
por: Hartley, Antja-Voy, et al.
Publicado: (2020)

Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
por: Krzyzanowski, Adrian, et al.
Publicado: (2022)

A novel immune-related gene pair prognostic signature for predicting overall survival in bladder cancer
por: Fu, Yang, et al.
Publicado: (2021)

Down-regulation LncRNA-SNHG15 contributes to proliferation and invasion of bladder cancer cells
por: Mokhtar, Aldhabi, et al.
Publicado: (2021)

Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer
por: Jiang, Zhenming, et al.
Publicado: (2015)

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls
por: Rapado, Ludmila N., et al.
Publicado: (2014)

Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice
por: Liu, Zhongbo, et al.
Publicado: (2022)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Epigenetic drug screening defines a PRMT5 inhibitor–sensitive pancreatic cancer subtype
por: Orben, Felix, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i4u3dh12533gsjvmkfu8kbh11c