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A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response

We develop a lattice-based, hybrid discrete-continuum modeling framework for SARS-CoV-2 exposure and infection in the human lung alveolar region, or parenchyma, the massive surface area for gas exchange. COVID-19 pneumonia is alveolar infection by the SARS-CoV-2 virus significant enough to compromis...

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Detalles Bibliográficos
Autores principales: Aristotelous, Andreas C., Chen, Alex, Forest, M. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533651/
https://www.ncbi.nlm.nih.gov/pubmed/36208668
http://dx.doi.org/10.1016/j.jtbi.2022.111293