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miR‐126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis‐associated colorectal cancer

Inflammatory bowel disease, characterised by chronic relapsing‐remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR‐126 functions as a tumour suppressor in CRC and is inversely correlated with tumour proliferation, metastasis and patient prognos...

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Detalles Bibliográficos
Autores principales: Wu, Shuai, Yuan, Wei, Luo, Weiwei, Nie, Kai, Wu, Xing, Meng, Xiangrui, Shen, Zhaohua, Wang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533691/
https://www.ncbi.nlm.nih.gov/pubmed/35363937
http://dx.doi.org/10.1002/1878-0261.13218