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Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox
Numerous animal models of systemic orthopoxvirus disease have been developed to evaluate therapeutics against variola virus (VARV), the causative agent of smallpox. These animal models do not resemble the disease presentation in human smallpox and most used surrogate Orthopoxviruses. A rodent model...
Autores principales: | Gallardo-Romero, Nadia F., Hutson, Christina L., Carroll, Darin, Kondas, Ashley V., Salzer, Johanna S., Dietz-Ostergaard, Sharon, Smith, Scott, Hudson, Paul, Olson, Victoria, Damon, Inger |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533991/ https://www.ncbi.nlm.nih.gov/pubmed/31593747 http://dx.doi.org/10.1016/j.virusres.2019.197772 |
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