Cargando…
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand the impact of aging on beta cells, we performed meta-analysis of single-cell RNA sequencing datasets, transcription factor (TF) regulon analysis, high-resolution confocal microscopy, and measured insulin sec...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534504/ https://www.ncbi.nlm.nih.gov/pubmed/36197983 http://dx.doi.org/10.1126/sciadv.abo3932 |