Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress

Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand the impact of aging on beta cells, we performed meta-analysis of single-cell RNA sequencing datasets, transcription factor (TF) regulon analysis, high-resolution confocal microscopy, and measured insulin sec...

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Detalles Bibliográficos
Autores principales: Shrestha, Shristi, Erikson, Galina, Lyon, James, Spigelman, Aliya F., Bautista, Austin, Manning Fox, Jocelyn E., dos Santos, Cristiane, Shokhirev, Maxim, Cartailler, Jean-Philippe, Hetzer, Martin W., MacDonald, Patrick E., Arrojo e Drigo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534504/
https://www.ncbi.nlm.nih.gov/pubmed/36197983
http://dx.doi.org/10.1126/sciadv.abo3932

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