Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not essential in vivo. We hypothesize that spontaneous mu...

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Detalles Bibliográficos
Autores principales: Monterisi, Stefania, Michl, Johanna, Hulikova, Alzbeta, Koth, Jana, Bridges, Esther M, Hill, Amaryllis E, Abdullayeva, Gulnar, Bodmer, Walter F, Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534548/
https://www.ncbi.nlm.nih.gov/pubmed/36107487
http://dx.doi.org/10.7554/eLife.78425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534548/
https://www.ncbi.nlm.nih.gov/pubmed/36107487
http://dx.doi.org/10.7554/eLife.78425

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