Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs

The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a series of benzofuran oxoacetic acid EPAC1 activators, SY006, SY007 and SY009. Protein inter...

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Detalles Bibliográficos
Autores principales: Wiejak, Jolanta, Luchowska-Stańska, Urszula, Wang, Pingyuan, Zhou, Jia, Maffia, Pasquale, Morgan, David, Barker, Graeme, Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534843/
https://www.ncbi.nlm.nih.gov/pubmed/36198739
http://dx.doi.org/10.1038/s41598-022-20607-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534843/
https://www.ncbi.nlm.nih.gov/pubmed/36198739
http://dx.doi.org/10.1038/s41598-022-20607-8

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