BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity

Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating macrophage efferocytosis. Studies are underway to develop small-molecule chemicals that inhibit MERTK as cancer immunotherapeutic agents, but these effor...

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Detalles Bibliográficos
Autores principales: Bae, Seung-Hyun, Kim, Jung-Hoon, Park, Tae Hyun, Lee, Kyeong, Lee, Byung Il, Jang, Hyonchol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534909/
https://www.ncbi.nlm.nih.gov/pubmed/36056187
http://dx.doi.org/10.1038/s12276-022-00840-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534909/
https://www.ncbi.nlm.nih.gov/pubmed/36056187
http://dx.doi.org/10.1038/s12276-022-00840-x

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