Cargando…

BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity

Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating macrophage efferocytosis. Studies are underway to develop small-molecule chemicals that inhibit MERTK as cancer immunotherapeutic agents, but these effor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bae, Seung-Hyun, Kim, Jung-Hoon, Park, Tae Hyun, Lee, Kyeong, Lee, Byung Il, Jang, Hyonchol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534909/ https://www.ncbi.nlm.nih.gov/pubmed/36056187 http://dx.doi.org/10.1038/s12276-022-00840-x

Ejemplares similares

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development
por: Park, Tae Hyun, et al.
Publicado: (2020)

Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx
por: Yang, Susumin, et al.
Publicado: (2023)

Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis
por: Moon, Byeongjin, et al.
Publicado: (2020)

Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3
por: Mytych, Joshua S, et al.
Publicado: (2023)

Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages
por: Wanke, Florian, et al.
Publicado: (2021)

NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway
por: Wang, Yue, et al.
Publicado: (2023)

MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines
por: Kim, Jung Eun, et al.
Publicado: (2017)

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis
por: Chakraborty, Sreeparna, et al.
Publicado: (2023)

Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis
por: She, Yixin, et al.
Publicado: (2023)

The Tolerogenic Influence of Dexamethasone on Dendritic Cells Is Accompanied by the Induction of Efferocytosis, Promoted by MERTK
por: Li, Vivien, et al.
Publicado: (2023)

Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
por: Myers Chen, Kayla V., et al.
Publicado: (2023)

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
por: Cruz Cruz, Joselyn, et al.
Publicado: (2023)

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients
por: Mohd Idrus, Fatin Najiah, et al.
Publicado: (2021)

Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages
por: Ouyang, Junjie, et al.
Publicado: (2020)

Modulation of Macrophage Efferocytosis in Inflammation
por: Korns, Darlynn, et al.
Publicado: (2011)

Efferocytosis is impaired in Gaucher macrophages
por: Aflaki, Elma, et al.
Publicado: (2017)

MerTK is a novel therapeutic target in gastric cancer
por: Yi, Jun Ho, et al.
Publicado: (2015)

Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury
por: Soliman, Eman, et al.
Publicado: (2023)

Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/Mertk signaling following brain injury
por: Soliman, Eman, et al.
Publicado: (2023)

Dapagliflozin: BMS 512148; BMS-512148
Publicado: (2012)

Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
por: Pan, Zijian, et al.
Publicado: (2019)

Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation
por: Kim, Dong Keon, et al.
Publicado: (2020)

MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity
por: Lee-Sherick, Alisa B., et al.
Publicado: (2020)

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
por: Knubel, Kristina H., et al.
Publicado: (2014)

The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury
por: Jang, Eun-A, et al.
Publicado: (2019)

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression
por: Lin, Jinti, et al.
Publicado: (2022)

Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition
por: Lee, Seungheon, et al.
Publicado: (2023)

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
por: Horst, Andrea Kristina, et al.
Publicado: (2019)

Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas
por: Parv, Kristel, et al.
Publicado: (2021)

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis
por: Yang, M, et al.
Publicado: (2015)

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
por: Sufit, Alexandra, et al.
Publicado: (2016)

Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation
por: Lee, Seongheon, et al.
Publicado: (2020)

FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer
por: Kim, Young-Ho, et al.
Publicado: (2019)

MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS
por: Healy, Luke M., et al.
Publicado: (2017)

Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis
por: Lee, Suho, et al.
Publicado: (2015)

Zinc and Zinc Transporters in Macrophages and Their Roles in Efferocytosis in COPD
por: Hamon, Rhys, et al.
Publicado: (2014)

DEL-1 promotes macrophage efferocytosis and clearance of inflammation
por: Kourtzelis, Ioannis, et al.
Publicado: (2018)

Efferocytosis perpetuates substance accumulation inside macrophage populations
por: Ford, Hugh Z., et al.
Publicado: (2019)

Macrophage efferocytosis with VEGFC and lymphangiogenesis: rescuing the broken heart
por: D’Amore, Patricia A., et al.
Publicado: (2022)

Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation
por: Lee, Sang R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dnb1almic67fmu2h6ofc3c50j6