De Novo Design of an Androgen Receptor DNA Binding Domain‐Targeted peptide PROTAC for Prostate Cancer Therapy

Androgen receptor splice variant‐7 (AR‐V7), one of the major driving factors, is the most attractive drug target in castration‐resistant prostate cancer (CRPC). Currently, no available drugs efficiently target AR‐V7 in clinical practice. The DNA binding domain (DBD) is indispensable for the transcri...

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Detalles Bibliográficos
Autores principales: Ma, Bohan, Fan, Yizeng, Zhang, Dize, Wei, Yi, Jian, Yanlin, Liu, Donghua, Wang, Zixi, Gao, Yang, Ma, Jian, Chen, Yule, Xu, Shan, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534960/
https://www.ncbi.nlm.nih.gov/pubmed/35971165
http://dx.doi.org/10.1002/advs.202201859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534960/
https://www.ncbi.nlm.nih.gov/pubmed/35971165
http://dx.doi.org/10.1002/advs.202201859

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