Cargando…

O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy

Both O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory mechanisms that maintain cellular homeostasis and function in response to various stress conditions. Abnormalities in O-GlcNAcylation and ER-pha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Rongjin, Li, Gaocai, Zhang, Weifei, Liang, Huaizhen, Lu, Saideng, Cheung, Jason Pui Yin, Zhang, Teng, Tu, Ji, Liu, Hui, Liao, Zhiwei, Ke, Wencan, Wang, Bingjin, Song, Yu, Yang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535016/ https://www.ncbi.nlm.nih.gov/pubmed/36056188 http://dx.doi.org/10.1038/s12276-022-00844-7

Ejemplares similares

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells
por: Luo, Rongjin, et al.
Publicado: (2021)

X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body
por: Olivier-Van Stichelen, Stéphanie, et al.
Publicado: (2014)

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes
por: Kapuria, Vaibhav, et al.
Publicado: (2016)

Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis
por: Lin, Chia-Hung, et al.
Publicado: (2021)

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis
por: Park, Sung-Kyun, et al.
Publicado: (2017)

Structural insights into mechanism and specificity of O-GlcNAc transferase
por: Clarke, Andrew J, et al.
Publicado: (2008)

Structural snapshots of the reaction coordinate for O-GlcNAc transferase
por: Lazarus, Michael B., et al.
Publicado: (2012)

Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing
por: Liu, Tai‐Wei, et al.
Publicado: (2018)

Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei
por: Ji, Zhe, et al.
Publicado: (2021)

Substrate and product analogues as human O-GlcNAc transferase inhibitors
por: Dorfmueller, Helge C., et al.
Publicado: (2010)

Dual functionality of O-GlcNAc transferase is required for Drosophila development
por: Mariappa, Daniel, et al.
Publicado: (2015)

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
por: Hu, Chia-Wei, et al.
Publicado: (2017)

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins
por: Trapannone, Riccardo, et al.
Publicado: (2016)

Chemoproteomic profiling of O‐GlcNAcylated proteins and identification of O‐GlcNAc transferases in rice
por: Li, Xilong, et al.
Publicado: (2023)

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
por: Borodkin, Vladimir S., et al.
Publicado: (2014)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis
por: Schimpl, Marianne, et al.
Publicado: (2012)

A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin
por: Gambetta, Maria Cristina, et al.
Publicado: (2015)

Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors
por: Rafie, Karim, et al.
Publicado: (2018)

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
por: Rafie, Karim, et al.
Publicado: (2017)

O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes
por: Barkovskaya, Anna, et al.
Publicado: (2019)

O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension
por: Barnes, Jarrod W., et al.
Publicado: (2019)

An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase
por: Pravata, Veronica M., et al.
Publicado: (2020)

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
por: Weiss, Matjaž, et al.
Publicado: (2021)

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability
por: Mitchell, Conor W., et al.
Publicado: (2022)

Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel
por: Xia, Mingyue, et al.
Publicado: (2022)

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain
por: Liu, Ying, et al.
Publicado: (2012)

Regulation of the Proteasome by AMPK in Endothelial Cells: The Role of O-GlcNAc Transferase (OGT)
por: Xu, Jian, et al.
Publicado: (2012)

Structure of human O-GlcNAc transferase and its complex with a peptide substrate
por: Lazarus, Michael B., et al.
Publicado: (2011)

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability
por: Pravata, Veronica M., et al.
Publicado: (2019)

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
por: Itkonen, Harri M., et al.
Publicado: (2016)

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis
por: Yu, Fan, et al.
Publicado: (2020)

O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition
por: Gondane, Aishwarya, et al.
Publicado: (2022)

Corrigendum: Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel
por: Xia, Mingyue, et al.
Publicado: (2023)

Critical roles of FAM134B in ER-phagy and diseases
por: Mo, Jie, et al.
Publicado: (2020)

Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V
Publicado: (1995)

A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase
por: Jiang, Jiaoyang, et al.
Publicado: (2011)

A Modified Coupled Enzyme Method for O-linked GlcNAc Transferase Activity Assay
por: Zhang, Lianwen, et al.
Publicado: (2009)

Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation
por: Seo, Hyeon Gyu, et al.
Publicado: (2016)

OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A
por: Simon, Dan N., et al.
Publicado: (2018)

Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
por: Willems, Anke P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_andbfjpe244g7fbnve9gl8ddhi