Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization

BACKGROUND: Radiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint inhibition (ICI). We investigated whether the commonl...

Descripción completa

Detalles Bibliográficos
Autores principales: Jagodinsky, Justin C, Bates, Amber M, Clark, Paul A, Sriramaneni, Raghava N, Havighurst, Thomas C, Chakravarty, Ishan, Nystuen, Erin J, Kim, KyungMann, Sondel, Paul M, Jin, Won Jong, Morris, Zachary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535200/
https://www.ncbi.nlm.nih.gov/pubmed/36192087
http://dx.doi.org/10.1136/jitc-2022-005103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535200/
https://www.ncbi.nlm.nih.gov/pubmed/36192087
http://dx.doi.org/10.1136/jitc-2022-005103

Ejemplares similares