Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear. In this study, we investigated the potential role and molecular mec...

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Detalles Bibliográficos
Autores principales: Abdelghany, Lina, Kawabata, Tsuyoshi, Goto, Shinji, Jingu, Keiichi, Li, Tao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535466/
https://www.ncbi.nlm.nih.gov/pubmed/36206675
http://dx.doi.org/10.1016/j.tranon.2022.101548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535466/
https://www.ncbi.nlm.nih.gov/pubmed/36206675
http://dx.doi.org/10.1016/j.tranon.2022.101548

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