Addition of Lauryldimethylamine N-Oxide (LDAO) to a Copper-Free Click Chemistry Reaction Improves the Conjugation Efficiency of a Cell-Free Generated CRM197 Variant to Clinically Important Streptococcus pneumoniae Serotypes

[Image: see text] Strain-promoted azide–alkyne cycloaddition (SPAAC) reactions like click chemistry have the potential to be highly scalable, robust, and cost-effective methods for generating small- and large-molecule conjugates for a variety of applications. However, despite method improvements, th...

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Detalles Bibliográficos
Autores principales: Bautista, Leslie, Pill-Pepe, Lucy, Kapoor, Neeraj, Snyder, Scott, Chu, Ellen, Agarwal, Paresh, Sardar, Mohammed, Arulkumar, Shylaja, Berges, Aym, Iverson, Mark, Behrens, Christopher, Marcq, Olivier, Fairman, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535640/
https://www.ncbi.nlm.nih.gov/pubmed/36211053
http://dx.doi.org/10.1021/acsomega.2c03481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535640/
https://www.ncbi.nlm.nih.gov/pubmed/36211053
http://dx.doi.org/10.1021/acsomega.2c03481

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