Structural insights into the assembly and activation of the IL‐27 signaling complex

Interleukin 27 (IL‐27) is a heterodimeric cytokine that elicits potent immunosuppressive responses. Comprised of EBI3 and p28 subunits, IL‐27 binds GP130 and IL‐27Rα receptor chains to activate the JAK/STAT signaling cascade. However, how these receptors recognize IL‐27 and form a complex capable of...

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Detalles Bibliográficos
Autores principales: Jin, Yibo, Fyfe, Paul K, Gardner, Scott, Wilmes, Stephan, Bubeck, Doryen, Moraga, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535766/
https://www.ncbi.nlm.nih.gov/pubmed/35920255
http://dx.doi.org/10.15252/embr.202255450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535766/
https://www.ncbi.nlm.nih.gov/pubmed/35920255
http://dx.doi.org/10.15252/embr.202255450

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