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Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway

BACKGROUND: Hypoxia naturally happens in embryogenesis and thus serves as an important environmental factor affecting embryo development. Hif-1α, an essential hypoxia response factor, was mostly considered to mediate or synergistically regulate the effect of hypoxia on stem cells. However, the funct...

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Detalles Bibliográficos
Autores principales: Shen, Xiaopeng, Li, Meng, Wang, Chunguang, Liu, Zhongxian, Wu, Kun, Wang, Ao, Bi, Chao, Lu, Shan, Long, Hongan, Zhu, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536055/
https://www.ncbi.nlm.nih.gov/pubmed/36199093
http://dx.doi.org/10.1186/s12915-022-01423-y