V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy

Pore-forming toxins (PFTs) are important virulence factors produced by many pathogenic bacteria. Here, we show that the Vibrio cholerae toxin MakA is a novel cholesterol-binding PFT that induces non-canonical autophagy in a pH-dependent manner. MakA specifically binds to cholesterol on the membrane...

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Detalles Bibliográficos
Autores principales: Jia, Xiaotong, Knyazeva, Anastasia, Zhang, Yu, Castro-Gonzalez, Sergio, Nakamura, Shuhei, Carlson, Lars-Anders, Yoshimori, Tamotsu, Corkery, Dale P., Wu, Yao-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536202/
https://www.ncbi.nlm.nih.gov/pubmed/36194176
http://dx.doi.org/10.1083/jcb.202206040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536202/
https://www.ncbi.nlm.nih.gov/pubmed/36194176
http://dx.doi.org/10.1083/jcb.202206040

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