The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis

Cardiovascular diseases, especially atherosclerosis and its complications, are a leading cause of death. Inhibition of the noncanonical IκB kinases TANK-binding kinase 1 and IKKε with amlexanox restores insulin sensitivity and glucose homeostasis in diabetic mice and human patients. Here we report t...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Sun, Xiaoli, Liao, Zhongji, Yu, Hong, Li, Dan, Shen, Zeyang, Glass, Christopher K., Witztum, Joseph L., Saltiel, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536260/
https://www.ncbi.nlm.nih.gov/pubmed/35917178
http://dx.doi.org/10.1172/jci.insight.155552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536260/
https://www.ncbi.nlm.nih.gov/pubmed/35917178
http://dx.doi.org/10.1172/jci.insight.155552

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