Combined heterozygosity of FLT3(ITD), TET2, and DNMT3A results in aggressive leukemia

Heterozygous mutations in FLT3(ITD), TET2, and DNMT3A are associated with hematologic malignancies in humans. In patients, cooccurrence of mutations in FLT3(ITD) combined with TET2 (TF) or FLT3(ITD) combined with DNMT3A (DF) are frequent. However, in some rare complex acute myeloid leukemia (AML), a...

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Detalles Bibliográficos
Autores principales: Ramdas, Baskar, Lakshmi Reddy, Palam, Mali, Raghuveer Singh, Pasupuleti, Santhosh Kumar, Zhang, Ji, Kelley, Mark R., Paczesny, Sophie, Zhang, Chi, Kapur, Reuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536269/
https://www.ncbi.nlm.nih.gov/pubmed/36073548
http://dx.doi.org/10.1172/jci.insight.162016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536269/
https://www.ncbi.nlm.nih.gov/pubmed/36073548
http://dx.doi.org/10.1172/jci.insight.162016

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