MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression

Development of resistance to chemo- and immunotherapies often occurs following treatment of melanoma brain metastasis (MBM). The brain microenvironment (BME), particularly astrocytes, cooperate toward MBM progression by upregulating secreted factors, among which we found that monocyte chemoattractan...

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Detalles Bibliográficos
Autores principales: Pozzi, Sabina, Scomparin, Anna, Ben-Shushan, Dikla, Yeini, Eilam, Ofek, Paula, Nahmad, Alessio D., Soffer, Shelly, Ionescu, Ariel, Ruggiero, Antonella, Barzel, Adi, Brem, Henry, Hyde, Thomas M., Barshack, Iris, Sinha, Sanju, Ruppin, Eytan, Weiss, Tomer, Madi, Asaf, Perlson, Eran, Slutsky, Inna, Florindo, Helena F., Satchi-Fainaro, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536270/
https://www.ncbi.nlm.nih.gov/pubmed/35980743
http://dx.doi.org/10.1172/jci.insight.154804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536270/
https://www.ncbi.nlm.nih.gov/pubmed/35980743
http://dx.doi.org/10.1172/jci.insight.154804

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