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Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER(+) breast cancer. The ESR1 Y537S mutation, in particular, is associated with development of resistance to most en...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536271/ https://www.ncbi.nlm.nih.gov/pubmed/35881485 http://dx.doi.org/10.1172/jci.insight.151851 |