The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice

STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop αβ T cell–dependent lung disease and also lack lymph node...

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Detalles Bibliográficos
Autores principales: Stinson, W. Alexander, Miner, Cathrine A., Zhao, Fang R., Lundgren, Annena Jane, Poddar, Subhajit, Miner, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536275/
https://www.ncbi.nlm.nih.gov/pubmed/36073546
http://dx.doi.org/10.1172/jci.insight.155250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536275/
https://www.ncbi.nlm.nih.gov/pubmed/36073546
http://dx.doi.org/10.1172/jci.insight.155250

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