Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor–induced diabetes

Checkpoint inhibitors (CPIs) targeting programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) have revolutionized cancer treatment but can trigger autoimmune complications, including CPI-induced diabetes mellitus (CPI-DM), which occurs preferentiall...

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Detalles Bibliográficos
Autores principales: Perdigoto, Ana Luisa, Deng, Songyan, Du, Katherine C., Kuchroo, Manik, Burkhardt, Daniel B., Tong, Alexander, Israel, Gary, Robert, Marie E., Weisberg, Stuart P., Kirkiles-Smith, Nancy, Stamatouli, Angeliki M., Kluger, Harriet M., Quandt, Zoe, Young, Arabella, Yang, Mei-Ling, Mamula, Mark J., Pober, Jordan S., Anderson, Mark S., Krishnaswamy, Smita, Herold, Kevan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536276/
https://www.ncbi.nlm.nih.gov/pubmed/35925682
http://dx.doi.org/10.1172/jci.insight.156330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536276/
https://www.ncbi.nlm.nih.gov/pubmed/35925682
http://dx.doi.org/10.1172/jci.insight.156330

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