Silver-Catalyzed Controlled Intermolecular Cross-Coupling of Silyl Enol Ethers: Scalable Access to 1,4-Diketones

[Image: see text] A protocol for silver-catalyzed controlled intermolecular cross-coupling of silyl enolates is disclosed. The protocol displays good functional group tolerance and allows efficient preparation of a series of synthetically useful 1,4-diketones. Preliminary mechanistic investigations...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Li, Liu, Xiaoyi, Alvey, Gregory R., Shatskiy, Andrey, Liu, Jian-Quan, Kärkäs, Markus D., Wang, Xiang-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536665/
https://www.ncbi.nlm.nih.gov/pubmed/35713416
http://dx.doi.org/10.1021/acs.orglett.2c01477
Descripción
Sumario:[Image: see text] A protocol for silver-catalyzed controlled intermolecular cross-coupling of silyl enolates is disclosed. The protocol displays good functional group tolerance and allows efficient preparation of a series of synthetically useful 1,4-diketones. Preliminary mechanistic investigations suggest that the reaction proceeds through a one-electron process involving free radical species in which PhBr acts as the oxidant.

Ejemplares similares