Dynamic allostery in substrate binding by human thymidylate synthase

Human thymidylate synthase (hTS) is essential for DNA replication and therefore a therapeutic target for cancer. Effective targeting requires knowledge of the mechanism(s) of regulation of this 72 kDa homodimeric enzyme. Here, we investigate the mechanism of binding cooperativity of the nucleotide s...

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Detalles Bibliográficos
Autores principales: Bonin, Jeffrey P, Sapienza, Paul J, Lee, Andrew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536839/
https://www.ncbi.nlm.nih.gov/pubmed/36200982
http://dx.doi.org/10.7554/eLife.79915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536839/
https://www.ncbi.nlm.nih.gov/pubmed/36200982
http://dx.doi.org/10.7554/eLife.79915

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