Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

Pleiotropy and genetic correlation are widespread features in genome-wide association studies (GWAS), but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino acid catabolism, glycolysis, and ketone body metaboli...

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Detalles Bibliográficos
Autores principales: Smith, Courtney J, Sinnott-Armstrong, Nasa, Cichońska, Anna, Julkunen, Heli, Fauman, Eric B, Würtz, Peter, Pritchard, Jonathan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536840/
https://www.ncbi.nlm.nih.gov/pubmed/36073519
http://dx.doi.org/10.7554/eLife.79348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536840/
https://www.ncbi.nlm.nih.gov/pubmed/36073519
http://dx.doi.org/10.7554/eLife.79348

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