Selective optogenetic activation of Na(V)1.7–expressing afferents in Na(V)1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

In small and large spinal dorsal root ganglion neurons, subtypes of voltage-gated sodium channels, such as Na(V)1.7, Na(V)1.8, and Na(V)1.9 are expressed with characteristically localized and may play different roles in pain transmission and intractable pain development. Selective stimulation of eac...

Descripción completa

Detalles Bibliográficos
Autores principales: Maruta, Toyoaki, Hidaka, Kotaro, Kouroki, Satoshi, Koshida, Tomohiro, Kurogi, Mio, Kage, Yohko, Mizuno, Seiya, Shirasaka, Tetsuro, Yanagita, Toshihiko, Takahashi, Satoru, Takeya, Ryu, Tsuneyoshi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536842/
https://www.ncbi.nlm.nih.gov/pubmed/36201719
http://dx.doi.org/10.1371/journal.pone.0275751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536842/
https://www.ncbi.nlm.nih.gov/pubmed/36201719
http://dx.doi.org/10.1371/journal.pone.0275751

Ejemplares similares