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Selective optogenetic activation of Na(V)1.7–expressing afferents in Na(V)1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli
In small and large spinal dorsal root ganglion neurons, subtypes of voltage-gated sodium channels, such as Na(V)1.7, Na(V)1.8, and Na(V)1.9 are expressed with characteristically localized and may play different roles in pain transmission and intractable pain development. Selective stimulation of eac...
Autores principales: | Maruta, Toyoaki, Hidaka, Kotaro, Kouroki, Satoshi, Koshida, Tomohiro, Kurogi, Mio, Kage, Yohko, Mizuno, Seiya, Shirasaka, Tetsuro, Yanagita, Toshihiko, Takahashi, Satoru, Takeya, Ryu, Tsuneyoshi, Isao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536842/ https://www.ncbi.nlm.nih.gov/pubmed/36201719 http://dx.doi.org/10.1371/journal.pone.0275751 |
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