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The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes

Severe brain metabolic dysfunction and amyloid-β accumulation are key hallmarks of Alzheimer’s disease (AD). While astrocytes contribute to both pathologic mechanisms, the role of their mitochondria, which is essential for signaling and maintenance of these processes, has been largely understudied....

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Detalles Bibliográficos
Autores principales: Metodieva, Vanya, Smith, Terry, Gunn-Moore, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536859/
https://www.ncbi.nlm.nih.gov/pubmed/36096650
http://dx.doi.org/10.1523/ENEURO.0040-22.2022