Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity

BACKGROUND: Second- and third-generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) are associated with cardiovascular adverse events (CVAEs) in patients with Philadelphia chromosome–positive (Ph+) leukemia. OBJECTIVES: We hypothesized that second- and third-generation BCR-ABL1 TKIs may cause CVAEs...

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Detalles Bibliográficos
Autores principales: Yu, Brian, Osman, Afaf E.G., Sladojevic, Nikola, Prabhu, Nicole, Tai, Haw-Chih, Chen, Daiqing, Perla, Gerardo, Park, Linus, Larson, Richard A., Liao, James K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537085/
https://www.ncbi.nlm.nih.gov/pubmed/36213346
http://dx.doi.org/10.1016/j.jaccao.2022.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537085/
https://www.ncbi.nlm.nih.gov/pubmed/36213346
http://dx.doi.org/10.1016/j.jaccao.2022.06.004

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