A novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism

Congenital hyperinsulinism (CHI) is a rare genetic condition characterized by uncontrolled insulin secretion, resulting in hypoglycemia. Although glucagon has lately been regarded as a therapeutic option for CHI, its use is severely hampered by its poor solubility and stability at physiological pH,...

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Detalles Bibliográficos
Autores principales: Heo, Yong Ho, Kim, Jung Kuk, Lee, Jong Suk, Lee, Sang-Hyun, Shin, Seung-Hyun, Choi, In Young, Kim, Ha Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537296/
https://www.ncbi.nlm.nih.gov/pubmed/36202918
http://dx.doi.org/10.1038/s41598-022-21251-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537296/
https://www.ncbi.nlm.nih.gov/pubmed/36202918
http://dx.doi.org/10.1038/s41598-022-21251-y

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