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Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants

Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and cancers. However, the mechanism by which their cell surface receptors promote their uptake into dendritic cells (DCs) and shuttle them to intracellular Toll-...

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Detalles Bibliográficos
Autores principales: Kitagawa, Satoki, Matsuda, Teppei, Washizaki, Ayaka, Murakami, Hirotomo, Yamamoto, Takuya, Yoshioka, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537314/
https://www.ncbi.nlm.nih.gov/pubmed/36202858
http://dx.doi.org/10.1038/s41541-022-00541-6