TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence

ERG translocations are commonly involved in the initiation of prostate neoplasia, yet previous experimental approaches have not addressed mechanisms of oncogenic inception. Here, in a genetically-engineered mouse model, combining TMPRSS2-driven ERG with Kras(G12D) led to invasive prostate adenocarci...

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Detalles Bibliográficos
Autores principales: Fang, Lei, Li, Dongmei, Yin, JuanJuan, Pan, Hong, Ye, Huihui, Bowman, Joel, Capaldo, Brian, Kelly, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537368/
https://www.ncbi.nlm.nih.gov/pubmed/35393570
http://dx.doi.org/10.1038/s41417-022-00454-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537368/
https://www.ncbi.nlm.nih.gov/pubmed/35393570
http://dx.doi.org/10.1038/s41417-022-00454-5

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