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A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones

Sufficient concentration of antibiotics close to their target is key for antimicrobial action. Among the tools exploited by bacteria to reduce the internal concentration of antibiotics, multidrug efflux pumps stand out for their ability to capture and expel many unrelated compounds out of the cell....

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Detalles Bibliográficos
Autores principales: Vergalli, Julia, Chauvet, Hugo, Oliva, Francesco, Pajović, Jelena, Malloci, Giuliano, Vargiu, Attilio Vittorio, Réfrégiers, Matthieu, Ruggerone, Paolo, Pagès, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537517/
https://www.ncbi.nlm.nih.gov/pubmed/36203030
http://dx.doi.org/10.1038/s42003-022-04024-1