Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson’s disease (PD), which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; however, the precise mechanism has yet to be determined. We demonstrated for the first time that CTSL was mostly r...

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Detalles Bibliográficos
Autores principales: Jiang, Tianfang, Xu, Chuanying, Gao, Shane, Zhang, Jia, Zheng, Jia, Wu, Xiaolin, Lu, Qiuyun, Cao, Limei, Yang, Danjing, Xu, Jun, Chen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537534/
https://www.ncbi.nlm.nih.gov/pubmed/36202834
http://dx.doi.org/10.1038/s41531-022-00394-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537534/
https://www.ncbi.nlm.nih.gov/pubmed/36202834
http://dx.doi.org/10.1038/s41531-022-00394-9

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