Cargando…

Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson’s disease (PD), which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; however, the precise mechanism has yet to be determined. We demonstrated for the first time that CTSL was mostly r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Tianfang, Xu, Chuanying, Gao, Shane, Zhang, Jia, Zheng, Jia, Wu, Xiaolin, Lu, Qiuyun, Cao, Limei, Yang, Danjing, Xu, Jun, Chen, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537534/ https://www.ncbi.nlm.nih.gov/pubmed/36202834 http://dx.doi.org/10.1038/s41531-022-00394-9

Ejemplares similares

Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy
por: Liu, Jia, et al.
Publicado: (2017)

Microglia as modulators of exosomal alpha-synuclein transmission
por: Xia, Yun, et al.
Publicado: (2019)

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021)

Spermidine protects against α-synuclein neurotoxicity
por: Büttner, Sabrina, et al.
Publicado: (2014)

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
por: Zhang, Ya-Nan, et al.
Publicado: (2021)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity
por: Hu, Zhaoyang, et al.
Publicado: (2016)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
por: Roostaee, Alireza, et al.
Publicado: (2013)

N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity
por: Zhou, Lingyan, et al.
Publicado: (2022)

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2011)

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system
por: Kuter, Katarzyna Z., et al.
Publicado: (2021)

The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity
por: Aufschnaiter, Andreas, et al.
Publicado: (2017)

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2012)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
por: Sarkar, Souvarish, et al.
Publicado: (2021)

Cathepsin Oxidation Alters Alpha-Synuclein Processing
por: Ferree, Andrew W.
Publicado: (2019)

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease
por: McGlinchey, Ryan P., et al.
Publicado: (2019)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
por: Pacheco, C., et al.
Publicado: (2012)

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity
por: Das, Sukanya, et al.
Publicado: (2018)

Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
por: Chai, MuhChyi, et al.
Publicado: (2019)

Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro
por: Inden, Masatoshi, et al.
Publicado: (2021)

Methamphetamine neurotoxicity, microglia, and neuroinflammation
por: Shaerzadeh, Fatemeh, et al.
Publicado: (2018)

Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome
por: Yang, Yi, et al.
Publicado: (2017)

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
por: Brekk, Oeystein R., et al.
Publicado: (2020)

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
por: Taschenberger, Grit, et al.
Publicado: (2011)

Roles of Autophagy in MPP(+)-Induced Neurotoxicity In Vivo: The Involvement of Mitochondria and α-Synuclein Aggregation
por: Hung, Kai-Chih, et al.
Publicado: (2014)

Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson’s Disease
por: Kim, Heejeong, et al.
Publicado: (2022)

Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein
por: Dhakal, Shailendra, et al.
Publicado: (2022)

α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors
por: Conde, M. A., et al.
Publicado: (2023)

Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity
por: Pandit, Esha, et al.
Publicado: (2023)

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
por: Bae, E-J, et al.
Publicado: (2015)

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
por: Kim, Changyoun, et al.
Publicado: (2016)

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
por: Carija, Anita, et al.
Publicado: (2019)

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
por: Nicholatos, Justin W., et al.
Publicado: (2021)

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties
por: Bunk, Josina, et al.
Publicado: (2021)

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease
por: Zhao, Zhen-Hua, et al.
Publicado: (2019)

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
por: Fellner, Lisa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9t3d9raapoti6co515kn44n06u